Multi-scale Spatial Omics Platform

Spatial omics has taken off in recent years, helping us understand intercellular relationships by mapping the organization of cells within tissues.

Collecting detailed cellular information

With spatial techniques, we collect detailed cellular information and study the positional context of cells within tissues. Leveraging these technologies for your research allows you to better understand biological processes, such as cell-to-cell interactions between normal and diseased tissue. Within our team, we share the ambition to unravel disease drivers through in-depth studies of intercellular relationships with in patient tissues.

Catalyze the application of spatial technologies

The Multi-Scale Spatial Omics Platform is set up to catalyze the application of spatial technologies by merging expertise and providing support for spatial data collection and analysis. UMC Utrecht hosts several state-of-the-art spatial methodologies (including transcriptomics, proteomics and metabolomics), and we offer advice and solutions tailored to your scientific questions and research goals.

Collaborate with UMCU core facilities

Working closely with UMC Utrecht core facilities, we strengthen and advance the acquisition and analysis of high-spatial-resolution data. Several spatial technologies are already provided in service, including:

– Cell Microscopy Core: immunofluorescence, (immuno)electron microscopy
– UCyTOF: high-flex in situ single-cell imaging
– USeq: spatial transcriptomics and proteomics
– Utrecht MSI facility: in situ imaging of biomolecules such as peptides, lipids and metabolites.

These technologies enable us to study the expression and localization of mRNA, proteins, lipids and metabolites within their spatial tissue context. Unlocking tissue complexity with spatial omics provides greater insight into disease-promoting pathways and ultimately into new strategies to prevent or treat disease.