Single domain antibody services – QVQ

QVQ is specialized in the discovery of tailor-made sdAbs. Our lead-discovery projects can be customized for affinity, epitope specificity, cross-species recognition, or functional activity. Although sdAbs are conventionally based on animals, QVQ is actively pursuing animal-free and computational approaches as well.

Services

Our services can be divided into four areas:

1. Single domain antibody discovery

• Immunization of camelids including phage display library construction
• Use of synthetic libraries to avoid immunization
• Panning and screening using phage display of sdAb panels
• Production and initial characterization of lead candidates
• Upscaled production and custom labeling

All fee-for-service, no IP retained

2. Computational structural biology

• Computer guided affinity maturation
• VHH humanization using in house developed LLM
• Optimization of VHH for developability and derisking
• De novo design of VHH and minibinders

Performed on in house GPU workstation

3. Pharmacology services

• Epitope binning services
• Target engagement to verify target specificity
• Cellular signalling assays
• Off target screening

4. Off-the-shelf products

• Single domain antibodies of QVQ or in-licensed from UU
• C-direct tagged with free cysteine for directional coupling
• Custom labeling services with dyes, biotin or chelators
• Custom large scale production possible in e.coli, yeast or mammalian cells