Cellular Screening Technologies

Cutting-edge pre-clinical human cellular disease models play a critical role in understanding complex biology and developing novel therapeutic strategies across various disease areas. However, translating these bench-scale disease models into trustworthy, standardized models that directly impact patient care requires advanced capabilities. The UMC Utrecht Advanced Technology Platform for Cellular Screening Technologies is designed to provide these crucial next steps: standardization, automated screening, and significantly increased throughput.

Core Services & Capabilities

• Model Automation: Development of automated human cellular disease models, facilitating the complex transition from bench-scale experimental setups to fully automated workflows.
• High-Throughput Screening: Advanced microscopy-based medium- to high-throughput cellular screening. This includes comprehensive support for 2D and 3D cultures, high-content analysis, and live-cell imaging.
• Expert Consultancy: Professional guidance in pre-clinical lab automation, including strategic experimental design to optimize screening outcomes.

Facility Equipment

The facility is currently anchored by “Rosie,” a fully automated platform dedicated to advanced assay automation. Developed in collaboration with the EWUU Centre for Living Technologies, the Rosie platform is housed at the Regenerative Medicine Centre Utrecht (Hubrecht location) and provides state-of-the-art infrastructure for high-throughput automated research. Further expansion of the equipment will follow in the coming years.

See also Ombion Centre for Animal-free Biomedical Translation.