Hubrecht Imaging Center

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Imaging is becoming increasingly important in the biomedical sciences and in research at the Hubrecht Institute. To meet the growing demand for advanced imaging equipment, the Hubrecht Imaging Center (HIC) was established in 2009. In recent years, the Hubrecht Institute has acquired a range of state of the art microscopes, which are now managed by the HIC.

The HIC supports a wide spectrum of imaging needs, from simple phase contrast imaging to high resolution imaging of living tissue. Advanced systems ar available at the HIC include confocal, two photon, TIRF, FRAP, STED and FRET microscopy, including FLIM. We have also spinning disk systems and light sheet microscopes.

The HIC ensures that the Hubrecht Institute’s advanced imaging equipment functions optimally and is used to its full potential. This is achieved through regular system testing and optimization, training new researchers, and providing support for imaging experiments.

Cell Microscopy Core (CMC)

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Cell Microscopy Core (CMC), is an expertise center for microscopy at the subcellular, cellular and tissue level. CMC is specialized in, and internationally renowned for immuno-electron microscopy (immunogold labeling of Tokuyasu cryosections) and correlative light-electron microscopy (CLEM). These methods uniquely allow the study of molecules at the nanoscale, within the ultrastructural context of the cell.

CMC is ratified as the CLEM node within the national Roadmap projects Netherlands Electron Microscopy Infrastructure (NEMI) and NL-BioImaging, as well as the European ESFRI project EuroBioImaging.
The infrastructure of CMC comprises equipment for EM sample preparation of biological specimens, fluorescent microscopy, live-cell imaging, transmission EM, FIB-SEM and CLEM. Together this covers a full range of microscopy methods for integrated studies at the subcellular, cellular and tissue level.

Expert CMC staff provide microscopy training, assistance with experimental design and interpretation, microscopy and imaging analysis courses, and full project service. This effectively allows users to address fundamental and applied research questions that require molecular and ultrastructural information.